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. 1993 Apr;3(2):131-6.
doi: 10.1093/glycob/3.2.131.

The vascular E-selectin binds to the leukocyte integrins CD11/CD18

P Kotovuori  1 , E Tontti, R Pigott, M Shepherd, M Kiso, A Hasegawa, R Renkonen, P Nortamo, D C Altieri, C G Gahmberg
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The vascular E-selectin binds to the leukocyte integrins CD11/CD18

P Kotovuori et al. Glycobiology. 1993 Apr.

Abstract

Leukocyte adhesion involves at least three molecular families of adhesion proteins: the leukocyte integrins CD11/CD18, the intercellular adhesion molecules (ICAMs) and the carbohydrate-binding L-, E- and P-selectins. The intercellular adhesion molecules are well-known ligands for the CD11/CD18 integrins. We now show that E-selectin specifically binds to the sialyl Lex carbohydrate epitopes of leukocyte integrins. Thus, the different families of leukocyte adhesion molecules form an integrated adhesion network.

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