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. 1993 Jun;31(6):1586-91.
doi: 10.1128/jcm.31.6.1586-1591.1993.

Identification of four epitopes in hepatitis C virus core protein

P Ferroni  1 , G Mascolo, M Zaninetti, D Colzani, F Pregliasco, M Pirisi, F Barbone, V Gasparini
Affiliations

Identification of four epitopes in hepatitis C virus core protein

P Ferroni et al. J Clin Microbiol. 1993 Jun.

Abstract

We identified four epitopes in hepatitis C virus core protein by using the algorithm of Jameson and Wolf. G15V (amino acids [aa] 31 to 45) appears to be the immunodominant epitope, since it was able to detect antibodies to the core protein in all 40 patients and in 44 of 45 recombinant immunoblot assay-confirmed positive blood donors. This epitope is associated with a low frequency of false-positive results, as found with 522 negative blood donors. A strong reactivity was also observed with the Q15V epitope (aa 7 to 21), although this was associated with low specificity. Occasional reactivity to the R15P (aa 49 to 63) and P15R (aa 99 to 113) epitopes was observed. Q15V and G15V detected antibodies to core protein earlier than the other two epitopes.

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