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. 1993 Jul 9;261(5118):221-4.
doi: 10.1126/science.7687074.

mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels

A Butler  1 , S Tsunoda, D P McCobb, A Wei, L Salkoff
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mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels

A Butler et al. Science. .

Abstract

Complementary DNAs (cDNAs) from mSlo, a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes. The mSlo-encoded channel resembled "maxi" or BK (high conductance) channel types; single channel conductance was 272 picosiemens with symmetrical potassium concentrations. Whole cell and single channel currents were blocked by charybdotoxin, iberiotoxin, and tetraethylammonium ion. A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene.

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