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Comparative Study
. 1993 May;3(3):261-9.
doi: 10.1007/BF00212513.

NMR structure-based drug design

S W Fesik  1
Affiliations
Comparative Study

NMR structure-based drug design

S W Fesik. J Biomol NMR. 1993 May.

Abstract

NMR is a useful tool for rapidly determining the conformations of receptor-bound ligands and identifying those portions of the ligand in contact with the receptor. In addition, the complete 3D structures of receptors and ligand/receptor complexes can be obtained using recently developed heteronuclear multi-dimensional NMR techniques. This NMR-derived structural information is potentially useful for aiding in The design of improved pharmaceutical agents. Approaches for utilizing the NMR-derived structural information along with the computational tools that facilitate this process are discussed.

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References

    1. FEBS Lett. 1992 Aug 24;308(3):309-14 - PubMed
    1. Methods Enzymol. 1989;177:44-73 - PubMed
    1. Science. 1992 Aug 21;257(5073):1078-82 - PubMed
    1. Science. 1991 May 10;252(5007):836-9 - PubMed
    1. Science. 1992 May 1;256(5057):632-8 - PubMed

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