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. 1993 Jul;38(1):47-54.
doi: 10.1007/BF02783981.

Effect of copper sulfate on experimental atherosclerosis

M Vlad  1 , E Bordas, R Tomus, D Sava, E Farkas, G Uza
Affiliations

Effect of copper sulfate on experimental atherosclerosis

M Vlad et al. Biol Trace Elem Res. 1993 Jul.

Abstract

Serum copper concentration increases significantly (p < 0.01) in rats with experimental atherosclerosis compared to a control group. The serum zinc, the zinc, and copper concentration in abdominal aorta and in liver decreases significantly (p < 0.05) compared to the control group. Administration of copper sulfate for 100 d in these animals induces a significant increase of serum copper (p < 0.01), decrease of serum cholesterol (p < 0.05) and increase of liver copper concentration as compared with the group fed only a high cholesterol diet. In the aorta of these animals the copper concentration increases and edema and lipid infiltration are considerably less than in the group of animals fed only a high lipid diet.

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