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Comparative Study
. 1993 Jul;13(7):557-62.
doi: 10.1002/pd.1970130704.

First-trimester free beta (hCG) screening for Down syndrome

J N Macri  1 , K Spencer, D Aitken, K Garver, P D Buchanan, F Muller, A Boue
Affiliations
Comparative Study

First-trimester free beta (hCG) screening for Down syndrome

J N Macri et al. Prenat Diagn. 1993 Jul.

Abstract

Maternal serum free beta (hCG) levels are elevated (median 2.20 MOM) in the first trimester of pregnancy in 38 Down syndrome cases as compared with appropriate controls. This observation may form the basis for its use as a marker in screening for Down syndrome in the first trimester. Altered levels of the free beta analyte are observed in pregnancy conditions or complications other than Down syndrome.

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