Serotonin depletors, 5,7-dihydroxytryptamine and p-chlorophenylalanine, cause sprouting in the CNS of the adult snail
- PMID: 7693304
- DOI: 10.1016/0006-8993(93)91444-w
Serotonin depletors, 5,7-dihydroxytryptamine and p-chlorophenylalanine, cause sprouting in the CNS of the adult snail
Abstract
The effects of 5,7-dihydroxytryptamine (5,7-DHT) and p-chlorophenylalanine (PCPA) on neuronal morphology were investigated in Achatina fulica by backfilling the cerebrobuccal connective with nickel-lysine. Backfilling 21 days following injections of either 5,7-DHT or PCPA revealed supernumerary staining of fibers in different pathways of the cerebral and buccal ganglia and novel staining of somata in the cerebral ganglia. HPLC measurements confirm that drug treatments led to a 30-46% depletion of serotonin (5-HT) in the buccal ganglia. These results support the role suggested for 5-HT as a neuritogenic modulator and additionally advise caution in the use of pharmacological depletors in studies examining serotonergic function.
Similar articles
-
Modulation of in vivo neuronal sprouting by serotonin in the adult CNS of the snail.Cell Mol Neurobiol. 1996 Oct;16(5):561-76. doi: 10.1007/BF02152057. Cell Mol Neurobiol. 1996. PMID: 8956009 Free PMC article. Review.
-
5-HT depletion with 5,7-DHT, PCA and PCPA in mice: differential effects on the sensitivity to 5-MeODMT, 8-OH-DPAT and 5-HTP as measured by two nociceptive tests.Brain Res. 1988 Feb 2;440(1):42-52. doi: 10.1016/0006-8993(88)91157-2. Brain Res. 1988. PMID: 2965956
-
Transient depletion of serotonin in the nervous system of Helisoma.J Neurobiol. 1986 Sep;17(5):431-47. doi: 10.1002/neu.480170507. J Neurobiol. 1986. PMID: 3021901
-
Axonal regeneration and sprouting following injury to the cerebral-buccal connective in the snail Achatina fulica.J Comp Neurol. 1990 Oct 8;300(2):273-86. doi: 10.1002/cne.903000210. J Comp Neurol. 1990. PMID: 1701775
-
Some behavioral effects of serotonin depletion depend on method: a comparison of 5,7-dihydroxytryptamine, p-chlorophenylalanine, p-choloroamphetamine, and electrolytic raphe lesions.Ann N Y Acad Sci. 1978 Jun 12;305:532-55. doi: 10.1111/j.1749-6632.1978.tb31547.x. Ann N Y Acad Sci. 1978. PMID: 152081 Review. No abstract available.
Cited by
-
Distribution of catecholamines, indoleamines, and their precursors and metabolites in the scallop, Placopecten magellanicus (Bivalvia, Pectinidae).Cell Mol Neurobiol. 1995 Jun;15(3):371-86. doi: 10.1007/BF02089947. Cell Mol Neurobiol. 1995. PMID: 7553736 Free PMC article.
-
A developmental study of serotonin-immunoreactive neurons in the larval central nervous system of the spider crab Hyas araneus (Decapoda, Brachyura).Invert Neurosci. 1995;1(1):53-65. doi: 10.1007/BF02331832. Invert Neurosci. 1995. PMID: 9372132
-
Tyrosine hydroxylase-negative, dopaminergic neurons are targets for transmitter-depleting action of haloperidol in the snail brain.Cell Mol Neurobiol. 1996 Aug;16(4):451-61. doi: 10.1007/BF02150226. Cell Mol Neurobiol. 1996. PMID: 8879748 Free PMC article.
-
From oocyte to neuron: do neurotransmitters function in the same way throughout development?Cell Mol Neurobiol. 1996 Oct;16(5):537-59. doi: 10.1007/BF02152056. Cell Mol Neurobiol. 1996. PMID: 8956008 Free PMC article. Review.
-
The neuronal control of cardiac functions in Molluscs.Comp Biochem Physiol A Mol Integr Physiol. 2011 Oct;160(2):102-16. doi: 10.1016/j.cbpa.2011.06.014. Epub 2011 Jun 25. Comp Biochem Physiol A Mol Integr Physiol. 2011. PMID: 21736949 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
