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. 1993 Nov;94(2):313-6.
doi: 10.1111/j.1365-2249.1993.tb03449.x.

IgM and IgG antibodies to hepatitis C virus in patients with mixed cryoglobulinaemia

A L'Abbate  1 , S Cutrupi, M Rognetta, C Fabiano, A Craxi
Affiliations

IgM and IgG antibodies to hepatitis C virus in patients with mixed cryoglobulinaemia

A L'Abbate et al. Clin Exp Immunol. 1993 Nov.

Abstract

To assess the relationship between hepatitis C virus (HCV) infection and essential mixed cryoglobulinaemia (EMC), sera from 23 patients with EMC were tested for IgG and IgM antibodies to HCV antigens and for HCV RNA. Quantitative HCV antibody studies were performed on serum and purified cryoglobulin fractions. HCV antibodies of both IgG and IgM class were found in 22 (96%) patients. Ten of these were also HCV-RNA positives. Higher titres of anti-HCV IgM were present in the 11 patients with evidence of liver damage. Anti-HCV IgG antibodies were shown to be concentrated in the IgG fraction of cryoglobulins in all eight patients studied. These results strongly suggest a role for HCV in the pathogenesis of EMC.

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