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Comparative Study
. 1993 Oct;13(5):343-5; discussion 307-8.
doi: 10.1046/j.1468-2982.1993.1305343.x.

Serum interleukin-1 beta is increased in cluster headache

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Comparative Study

Serum interleukin-1 beta is increased in cluster headache

P Martelletti et al. Cephalalgia. 1993 Oct.

Abstract

We measured serum interleukin-1 beta (IL-1 beta) in 24 episodic cluster headache (CH) patients and 45 normal controls using a specific ELISA method. There was an increase in IL-1 beta in all CH patients compared to controls. IL-1 beta was further increased during the ictal phase of CH compared to patients between attacks and normal individuals. Between attacks, IL-1 beta was also significantly increased compared to controls. We suggest that these results represent an activation of the immune system in CH.

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