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Comparative Study
. 1976 Mar;9(3):381-3.
doi: 10.1128/AAC.9.3.381.

Simple assay for 5-fluorocytosine in the presence of amphotericin B

C A Kauffman, J A Carleton, P T Frame
Comparative Study

Simple assay for 5-fluorocytosine in the presence of amphotericin B

C A Kauffman et al. Antimicrob Agents Chemother. 1976 Mar.

Abstract

A simple method for the measurement of 5-fluorocytosine in the presence of amphotericin B is described. The antifungal activity of amphotericin B is abolished by heating serum at 100 C for 45 min. 5-Fluorocytosine is unaffected by this treatment, and serum levels can be subsequently assayed by either tube dilution or disk diffusion methods.

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References

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