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Clinical Trial
. 1975 Oct;34(5):416-21.
doi: 10.1136/ard.34.5.416.

Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen

A J Dixon, J Davies, T L Dormandy, E B Hamilton, P J Holt, R M Mason, M Thompson, J C Weber, D W Zutshi
Clinical Trial

Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen

A J Dixon et al. Ann Rheum Dis. 1975 Oct.

Abstract

Doses of 600 mg and 1200 mg of D(-)penicillamine daily were superior to a standard regimen of therapy in rheumatoid arthritis. The higher dose did not produce significantly greater therapeutic benefit in the group of patients so treated, although individual patients sometimes improved more. The frequency of rashes, blood dyscrasias, and withdrawals from the trial increased withe dosage. It is concluded that D(-)penicillamine is a useful treatment that the daily dose should be as low as possible, and that it should be increased at infrequent intervals only, with due regard to the likelihood of further improvement in relation to an increased risk of adverse reactions.

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References

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    1. Postgrad Med J. 1970 Oct;46(540):599-605 - PubMed

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