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. 1994 Dec 26;667(2):287-90.
doi: 10.1016/0006-8993(94)91509-1.

An immunohistochemical study of cathepsin E in Alzheimer-type dementia brains

H G Bernstein  1 , B Wiederanders
Affiliations

An immunohistochemical study of cathepsin E in Alzheimer-type dementia brains

H G Bernstein et al. Brain Res. .

Abstract

We studied the immunohistochemical localization of cathepsin E (cath E) in the brains of patients with Alzheimer disease (AD) and control brains. In the normal brain cathepsin E immunoreactivity was detectable in a small number (below 5%) of neocortical and hippocampal neurons. In AD brains cathepsin E antigen was revealed in most large cortical and hippocampal pyramids and in neurons of the Nuc. basalis of Meynert. Cathepsin E was also present in cerebral microvessels, microglia, and in senile plaques. The enzyme might play roles in the process of neurodegeneration taking place in AD.

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