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Review
. 1995 Mar 20;361(2-3):135-9.
doi: 10.1016/0014-5793(95)00159-7.

Phase separation in cytoplasm, due to macromolecular crowding, is the basis for microcompartmentation

H Walter  1 , D E Brooks
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Free article
Review

Phase separation in cytoplasm, due to macromolecular crowding, is the basis for microcompartmentation

H Walter et al. FEBS Lett. .
Free article

Abstract

The macromolecular diversity and concentrations in the fluid phase of cytoplasm constitute conditions necessary and sufficient for aqueous phase separation. Consequences of phase separation in cytoplasm, including its 'compartmentation', are inferred from analogies with the physicochemical properties of aqueous two-phase systems and with the partitioning behavior of biomaterials in them.

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