Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1995 Jan;48(1):55-9.
doi: 10.1016/0020-7292(94)02268-2.

Controlled ovarian hyperstimulation with or without intrauterine insemination for the treatment of unexplained infertility

O Gregoriou  1 , N Vitoratos, C Papadias, S Konidaris, A Gargaropoulos, C Louridas
Affiliations
Clinical Trial

Controlled ovarian hyperstimulation with or without intrauterine insemination for the treatment of unexplained infertility

O Gregoriou et al. Int J Gynaecol Obstet. 1995 Jan.

Abstract

Objective: To evaluate whether there are any benefits from intrauterine insemination (IUI) as opposed to timed intercourse (TI) in stimulated ovarian cycles in couples with longstanding, unexplained infertility.

Methods: Forty-six couples with diagnoses of unexplained infertility were evaluated in a crossover study after a total of 141 cycles. Sixty-seven cycles were with IUI after controlled ovarian hyperstimulation (COH) while 74 cycles were after COH and TI.

Results: The pregnancy rate after COH/TI was 16.7% and after COH/IUI 45.2%. Cycle fecundity however was 8.9% after COH/TI and 25.7% after COH/IUI, which is a statistically significant difference (P < 0.05).

Conclusions: A trial of human menopausal gonadotropin and IUI is justified in couples with prolonged infertility of unknown cause.

PubMed Disclaimer

Publication types

LinkOut - more resources