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. 1995 Jan;22(1):73-7.

Autoantibodies in Parry-Romberg syndrome: a serologic study of 14 patients

I Garcia-de la Torre  1 , J Castello-Sendra, T Esgleyes-Ribot, G Martinez-Bonilla, J Guerrerosantos, M J Fritzler
Affiliations
  • PMID: 7699686

Autoantibodies in Parry-Romberg syndrome: a serologic study of 14 patients

I Garcia-de la Torre et al. J Rheumatol. 1995 Jan.

Abstract

Objective: To determine autoantibody profiles of patients with Parry-Romberg syndrome (PRS).

Methods: Antinuclear antibodies (ANA) in 14 patients with PRS were studied by indirect immunofluorescence (IIF), immunodiffusion and immunoblotting. Antinative DNA antibodies and rheumatoid factor (RF) were also analyzed.

Results: ANA were positive in 8 patients (57%). The patterns of staining included nucleolar, nuclear speckled and homogeneous. Anticentromere antibodies were observed in 2 and antihistone antibodies in 3 sera. Rheumatoid factor was found in 5 (36%) sera. Antinative DNA or antibodies that precipitated rabbit thymus extract were not found in any patients.

Conclusion: The serologic abnormalities observed in this study suggests that autoimmunity could play a pathogenic role in PRS.

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