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. 1994 Dec;46(6):1528-32.
doi: 10.1038/ki.1994.437.

Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats

C E Whitworth  1 , S Fleming, A D Cumming, J J Morton, N J Burns, B C Williams, J J Mullins
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Free article

Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats

C E Whitworth et al. Kidney Int. 1994 Dec.
Free article

Abstract

Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.

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