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. 1978 Apr;75(4):1962-6.
doi: 10.1073/pnas.75.4.1962.

Immunogenicity of the envelope glycoprotein of avian sarcoma virus

M S Halpern, R R Friis

Immunogenicity of the envelope glycoprotein of avian sarcoma virus

M S Halpern et al. Proc Natl Acad Sci U S A. 1978 Apr.

Abstract

The expression of type E-specific glycoprotein in chick-helper factor-positive [chf(+)] chickens is not restricted to a certain stage of embryogenesis but persists in postembryonic life. This finding prompted an investigation of the immunogenicity of the viral envelope glycoprotein of exogenous avian sarcoma virus in chf(+) and chf(-) chickens. Sensitization of both classes of chickens resulted in the induction of detectable antibody reactivity to determinants of the glycoprotein that were type-specific as well as group-specific. Because group-specific determinants are present on type E-specific glycoprotein, these results link immunity to exogenous viral envelope glycoprotein in chf(+) chickens with autoreactivity. A model is proposed to rationalize the induction of reactivity in this system.

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References

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