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Review
. 1994 Dec;102 Suppl 10(Suppl 10):13-6.
doi: 10.1289/ehp.94102s1013.

Oxygen radicals, cytokines, adhesion molecules, and lung injury

P A Ward  1
Affiliations
Review

Oxygen radicals, cytokines, adhesion molecules, and lung injury

P A Ward. Environ Health Perspect. 1994 Dec.

Abstract

Inflammatory injury in the lung or dermis occurring after systemic activation of complement or after local deposition of immune complexes is related to local activation of tissue macrophages and/or recruitment of blood neutrophils. While requirements for cytokines (IL-1, TNF alpha, MCP-1) vary with the model of injury, requirements for adhesion molecules (beta 2 integrins, selectins, ICAM-1) differ. In most cases the immediate events related to tissue injury can be linked to toxic products from oxygen and L-arginine. Whether there is a single toxic product or a variety of toxic products remains to be determined. These data emphasize similarities and differences in the mechanisms of inflammatory injury, as a function of the inciting inflammatory agent and the organ system involved.

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