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Comparative Study
. 1995 Apr;114(2):385-91.
doi: 10.1017/s0950268800058015.

Prevalence of human astrovirus serotype 4: capsid protein sequence and comparison with other strains

M M Willcocks  1 , J B Kurtz, T W Lee, M J Carter
Affiliations
Comparative Study

Prevalence of human astrovirus serotype 4: capsid protein sequence and comparison with other strains

M M Willcocks et al. Epidemiol Infect. 1995 Apr.

Abstract

Astrovirus serotype 4 has increased in relative prevalence in the Oxford, UK area in 1993. The structural gene of human astrovirus serotype 4 has been sequenced and the results indicate that this protein differs substantially from serotypes 1 and 2. In particular, conservation at the C terminus is greatly reduced. However, amino acid substitutions in this region show a strong conservation in character suggesting that structural or functional constraints operate in this region.

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