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. 1995 Feb;48(2):106-12.
doi: 10.7164/antibiotics.48.106.

Isolation and biological activity of thielocins: novel phospholipase A2 inhibitors produced by Thielavia terricola RF-143

K Matsumoto  1 , K Tanaka, S Matsutani, R Sakazaki, H Hinoo, N Uotani, T Tanimoto, Y Kawamura, S Nakamoto, T Yoshida
Affiliations
Free article

Isolation and biological activity of thielocins: novel phospholipase A2 inhibitors produced by Thielavia terricola RF-143

K Matsumoto et al. J Antibiot (Tokyo). 1995 Feb.
Free article

Abstract

Thielocins A2 alpha, A2 beta, A3, B1, B2 and B3 were isolated as a novel family of phospholipase A2 inhibitors from the fermentation broth of Thielavia terricola RF-143 together with thielavins and thielocins A1 alpha and A1 beta. The most potent inhibitory activity (IC50 = 0.0033 microM) against rat group II phospholipase A2 was shown by thielocin A1 beta. Against human group II phospholipase A2, thielocin B3 (IC50 = 0.076 microM) was the most potent.

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