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. 1995 Feb;48(2):143-8.
doi: 10.7164/antibiotics.48.143.

A nitro analogue of staurosporine and other minor metabolites produced by a Streptomyces longisporoflavus strain

Y Cai  1 , A Fredenhagen, P Hug, H H Peter
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Free article

A nitro analogue of staurosporine and other minor metabolites produced by a Streptomyces longisporoflavus strain

Y Cai et al. J Antibiot (Tokyo). 1995 Feb.
Free article

Abstract

From the staurosporine-producing strain Streptomyces longisporoflavus R-19 various minor metabolites were isolated: They include a new compound with a nitro function in C-4' and other metabolites related to staurosporine. The new structures were elucidated by spectroscopic methods, mainly 1H NMR and 13C NMR and by comparison with TAN-1030A. The new compounds inhibited protein kinase C with IC50 values in the nanomolar range.

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