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Clinical Trial
. 1994 Nov;20(8):577-80.
doi: 10.1007/BF01705725.

Use of antithrombin III in critical patients

J M Díaz-Cremades  1 , R Lorenzo, M Sánchez, M J Moreno, M J Alsar, J M Bosch, L Fajardo, D González, D Guerrero
Affiliations
Clinical Trial

Use of antithrombin III in critical patients

J M Díaz-Cremades et al. Intensive Care Med. 1994 Nov.

Abstract

Objective: To evaluate the effect of the AT III concentrates upon the clinical evolution and hemostatic parameters.

Design: Prospective, open, randomized trial.

Patients and participants: Septic and multiple trauma patients admitted to our Intensive Care Unit.

Setting: Levels of AT III below 70% were used as criteria to choose 36 patients, 20 of whom received treatment with AT III and 16 did not.

Interventions: AT III concentrates were administered at an initial dose of 60 U/kg followed by 10 U/kg every six hours.

Results: The administration of AT III neither contributes to alterations in haemostasis, nor the clinical evolution (evaluated according to Apache II score).

Conclusions: The results suggest that the administration of AT III concentrates to critical patients with acquired low levels, but without manifest DIC, may not be justified; although further studies on a larger population are required to establish definite conclusions.

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