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. 1995 May;69(5):3233-6.
doi: 10.1128/JVI.69.5.3233-3236.1995.

Different roles of bases within the integration signal sequence of human immunodeficiency virus type 1 in vitro

T Yoshinaga  1 , T Fujiwara
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Different roles of bases within the integration signal sequence of human immunodeficiency virus type 1 in vitro

T Yoshinaga et al. J Virol. 1995 May.

Abstract

To investigate the roles of bases near the tips of each strand of the long terminal repeat of the human immunodeficiency virus type 1 in the integration reaction, we examined the efficiencies of both binding and integration activities of staggered-ended substrates and mismatched mutant substrates by the integration assay and the UV cross-linking assay. Our results suggest that some bases of the human immunodeficiency virus type 1 long terminal repeat are required primarily for binding, whereas others are more critical for later reaction steps in vitro.

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