doi: 10.1016/s0968-0004(00)88972-0.
The protein import receptor of mitochondria
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- PMID: 7709435
- DOI: 10.1016/s0968-0004(00)88972-0
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The protein import receptor of mitochondria
Trends Biochem Sci.
1995 Mar.
Abstract
Protein import into the mitochondria of Saccharomyces cerevisiae depends on two receptor subcomplexes composed of integral outer-membrane proteins. One subcomplex is the MAS37-MAS70 heterodimer, which preferentially recognizes the mature regions of precursor proteins associated with ATP-dependent cytosolic chaperones. The other subcomplex contains the acidic proteins MAS20 and MAS22, which recognize the positively charged targeting sequences of a wide variety of mitochondrial precursors. We propose that the two subcomplexes can act together as a single, multifunctional receptor that binds simultaneously to different regions of a precursor molecule.
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