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Review
. 1994 Dec;6(6):900-6.
doi: 10.1016/0952-7915(94)90011-6.

Genetic and pathogenic basis of autoimmune diabetes in NOD mice

D V Serreze  1 , E H Leiter
Affiliations
Review

Genetic and pathogenic basis of autoimmune diabetes in NOD mice

D V Serreze et al. Curr Opin Immunol. 1994 Dec.

Abstract

Non-obese diabetic (NOD) mice are an excellent model of T-cell mediated autoimmune insulin-dependent diabetes in humans. Recent studies in NOD mice have shown that this disease is a result of epistatic interactions between multiple genes, both inside and outside the major histocompatibility complex (MHC), generating T cells reactive against an expanding repertoire of autoantigens.

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