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Review
. 1994 Dec;4(6):893-901.
doi: 10.1016/0959-440x(94)90272-0.

Domain movements in protein kinases

S Cox  1 , E Radzio-Andzelm, S S Taylor
Affiliations
Review

Domain movements in protein kinases

S Cox et al. Curr Opin Struct Biol. 1994 Dec.

Abstract

Structural studies of the catalytic subunit of the cAMP-dependent protein kinase, both by crystallographic methods and in solution, reveal two conformations. Crystal structures of several other protein kinases have also been solved in the past year. With this combined information we can begin to define mobile domains and subdomains within the conserved catalytic core.

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