[Lipid metabolism and pregnancy induced hypertension]

Abstract

Lipid metabolism was studied in 30 healthy non-pregnant women, 35 normal pregnant women and 34 patients with pregnancy induced hypertension (PIH). Total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), LDL-C/HDL-C ratio, and athero-sclerosis index (AI) were determined. In comparison with the non-pregnant status, lipid levels did not increased during normal mid-trimester pregnancy, but significantly increased at late trimester of normal pregnancy (P < 0.05). There was no significant difference in lipid levels between normal late pregnancy and PIH of mild and moderate degree, but TG and AI were significantly higher in cases with severe PIH. It showed that: lipid profiles in severe PIH was characterized by type IV hyperlipidemia; high lipid levels during normal late pregnancy might be a physiological phenomenon which presents a risk factor for PIH; marked increase of TG and AI in severe PIH may result in a rise of lipid peroxide (LPO).