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Comparative Study
. 1995;16(1):25-9.
doi: 10.1016/0196-9781(94)00142-s.

Effect of angiotensin II on the proliferation of mammotrophs from the adult rat anterior pituitary in culture

Affiliations
Comparative Study

Effect of angiotensin II on the proliferation of mammotrophs from the adult rat anterior pituitary in culture

T Shinkai et al. Peptides. 1995.

Abstract

We measured the influence of prolactin-releasing neuropeptides on mammotroph proliferation in cultures of rat adenohypophysis cells using flow cytometry. Angiotensin II (AII) increased mammotroph proliferation. Other peptides with hormone-releasing activities did not promote growth. Tamoxifen inhibited mammotroph proliferation in control and AII-containing cultures and the inhibition was reversed with beta-estradiol. Saralasin, an AII receptor antagonist, suppressed not only AII-induced mammotroph proliferation but also luteinizing hormone-releasing hormone (LHRH)-induced proliferation. These results suggest that hypothalamic LHRH stimulates AII release from gonadotrophs and that AII, with estrogen, controls mammotroph proliferation in rat pituitary.

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