Effect of angiotensin II on the proliferation of mammotrophs from the adult rat anterior pituitary in culture
- PMID: 7716071
- DOI: 10.1016/0196-9781(94)00142-s
Effect of angiotensin II on the proliferation of mammotrophs from the adult rat anterior pituitary in culture
Abstract
We measured the influence of prolactin-releasing neuropeptides on mammotroph proliferation in cultures of rat adenohypophysis cells using flow cytometry. Angiotensin II (AII) increased mammotroph proliferation. Other peptides with hormone-releasing activities did not promote growth. Tamoxifen inhibited mammotroph proliferation in control and AII-containing cultures and the inhibition was reversed with beta-estradiol. Saralasin, an AII receptor antagonist, suppressed not only AII-induced mammotroph proliferation but also luteinizing hormone-releasing hormone (LHRH)-induced proliferation. These results suggest that hypothalamic LHRH stimulates AII release from gonadotrophs and that AII, with estrogen, controls mammotroph proliferation in rat pituitary.
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