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Case Reports
. 1995 Mar;2(2):164-7.

Interleukin-2 gene therapy in a patient with glioblastoma

R E Sobol  1 , H Fakhrai, D Shawler, R Gjerset, O Dorigo, C Carson, T Khaleghi, J Koziol, T A Shiftan, I Royston
Affiliations
  • PMID: 7719933
Case Reports

Interleukin-2 gene therapy in a patient with glioblastoma

R E Sobol et al. Gene Ther. 1995 Mar.

Abstract

A patient with glioblastoma multiforme (GBM) who had failed conventional therapy was treated with IL-2 gene therapy. The patient received 10 subcutaneous immunizations with autologous tumor cells and fibroblasts genetically modified to secrete IL-2 by retroviral gene transfer. An antitumor immune response mediated in part by CD8+ cytotoxic T cells was demonstrated with the patient's peripheral blood mononuclear cells. A magnetic resonance imaging (MRI) scan performed 4 weeks after the highest treatment dose revealed marked tumor necrosis. These results support the evaluation of this form of IL-2 gene therapy in additional patients with glioblastoma.

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