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. 1978;21(1-2):33-41.
doi: 10.1159/000130876.

Human tumor and rodent-human hybrid cells with an increased number of active human NORs

D A Miller, V G Dev, R Tantravahi, C M Croce, O J Miller

Human tumor and rodent-human hybrid cells with an increased number of active human NORs

D A Miller et al. Cytogenet Cell Genet. 1978.

Abstract

A human fibrosarcoma line, HT1080-6TG, with a near diploid number of chromosomes, has an average of 7.3 chromosomes with an Ag-stained nucleolus organizer region (NOR). Cells of this line with an increased number of chromosomes have an increased number of Ag-stained NORs. This cell line has been used as the human parent in constructing mouse-human and rat-human hybrids that segregate rodent chromosomes. The hybrid ccell lines, which have 100 or more chromosomes per cell, show a proportionate increase in the number of Ag-stained NORs (means, 11.4--16.8). The frequency of association of acrocentric chromosomes increases in a similar fashion. There is no evidence of inactivation of human NORs in these cells.

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