doi: 10.1159/000130881.
Induced Robertsonian fusions and tandem translocations in mammalian cell cultures
- PMID: 77213
- DOI: 10.1159/000130881
Item in Clipboard
Induced Robertsonian fusions and tandem translocations in mammalian cell cultures
Cytogenet Cell Genet.
1978.
Abstract
Cultures of a cattle cell line and a Peromyscus eremicus cell line recovering from a pulse-treatment with mitomycin C, actinomycin D, 33258 Hoechst, and nitrosoguanidine exhibited translocations between chromosomes at the centromeric regions (Robertsonian fusions) as well as between centromere and telomere and between telomeres (tandem translocations). The frequency of Robertsonian fusions was found to be dose-dependent and duration-dependent with the mitomycin treatment. Biarmed chromosomes resulting from fusions may be monocentric or dicentric. Analyses of clones isolated from treated cells suggested that fused chromosomes may perpetuate in the cell populations.
Similar articles
-
Mitomycin C effect on Robertsonian translocations.Ann Genet. 1988;31(3):162-6. Ann Genet. 1988. PMID: 3146941
-
A Robertsonian translocation, rob(2;28), found in Vietnamese cattle.Hereditas. 2000;133(1):19-23. doi: 10.1111/j.1601-5223.2000.t01-1-00019.x. Hereditas. 2000. PMID: 11206849
-
The induction of Robertsonian translocations by X-rays and mitomycin C in mouse cells.Mutat Res. 1994 Apr;323(4):189-96. doi: 10.1016/0165-7992(94)90032-9. Mutat Res. 1994. PMID: 7512689
-
Centric fusion translocations in cattle: a review.Vet Rec. 1985 May 11;116(19):516-8. doi: 10.1136/vr.116.19.516. Vet Rec. 1985. PMID: 3890351 Review.
-
Chromosomal Aberrations in Cattle.Genes (Basel). 2021 Aug 27;12(9):1330. doi: 10.3390/genes12091330. Genes (Basel). 2021. PMID: 34573313 Free PMC article. Review.
Cited by
-
Zoo-fluorescence in situ hybridization analysis of human and Indian muntjac karyotypes (Muntiacus muntjak vaginalis) reveals satellite DNA clusters at the margins of conserved syntenic segments.Chromosome Res. 1997 Jun;5(4):254-61. doi: 10.1023/B:CHRO.0000032298.22346.46. Chromosome Res. 1997. PMID: 9244453
-
Telomere replication, kinetochore organizers, and satellite DNA evolution.Proc Natl Acad Sci U S A. 1979 Sep;76(9):4566-70. doi: 10.1073/pnas.76.9.4566. Proc Natl Acad Sci U S A. 1979. PMID: 291989 Free PMC article.
-
High-throughput analysis of the satellitome revealed enormous diversity of satellite DNAs in the neo-Y chromosome of the cricket Eneoptera surinamensis.Sci Rep. 2017 Jul 25;7(1):6422. doi: 10.1038/s41598-017-06822-8. Sci Rep. 2017. PMID: 28743997 Free PMC article.
-
Mosaic 13 trisomy due to de novo 13/13 translocation with subsequent fission. Karyotype: 46,XX, - 13, + t(13;13)(p11;q11)/46,XX,del(13)(p11).Hum Genet. 1979 Jan 25;46(2):237-41. doi: 10.1007/BF00291927. Hum Genet. 1979. PMID: 422207
-
A somatic origin of homologous Robertsonian translocations and isochromosomes.Am J Hum Genet. 1994 Feb;54(2):290-302. Am J Hum Genet. 1994. PMID: 8304346 Free PMC article.