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. 1995 Apr 22;345(8956):1025-6.
doi: 10.1016/s0140-6736(95)90761-0.

Vertical transmission of hepatitis E virus

M S Khuroo  1 , S Kamili, S Jameel
Affiliations

Vertical transmission of hepatitis E virus

M S Khuroo et al. Lancet. .

Abstract

Little is known about vertical transmission of hepatitis E virus from infected mothers to their infants. We studied eight babies born to mothers infected with hepatitis E in third trimester. One baby was icteric at birth with elevated transaminases and four babies had anicteric hepatitis. Two babies were born with hypothermia and hypoglycaemia and died within 24 h; one had massive hepatic necrosis. Hepatitis E virus RNA was detected by PCR in cord or birth blood samples of five infants. Six infants had evidence of hepatitis E infection. We conclude that hepatitis E virus is commonly transmitted from infected mothers to their babies with significant perinatal morbidity and mortality.

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