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. 1976 Feb 27;144(1):29-37.
doi: 10.1007/BF00277300.

A yeast mutant defective in the processing of 27S r-RNA precursor

C Andrew, A K Hopper, B D Hall

A yeast mutant defective in the processing of 27S r-RNA precursor

C Andrew et al. Mol Gen Genet. .

Abstract

Among a group of 31 ts- yeast mutants screened electrophoretically for heat-sensitive synthesis of each stable RNA species, only mutant ts351 failed to accumulate 25S RNA at 36 degrees C. Pulse-labeling experiments at 36 degrees C showed that 35S and 27S precursors RNA and mature 18S r-RNA molecules are synthetized by ts351 cells but that 25S and 5.8S RNA species are not made and new 60S ribosomal sub-units are not assembled. The mutant is blocked at a specific point in r-RNA processing: the cutting of 27S to form 25S and 5.8S r-RNA.

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References

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