Transduction of imipenem resistance by the phage F-116 from a nosocomial strain of Pseudomonas aeruginosa isolated in Slovakia
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- PMID: 7725997
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Transduction of imipenem resistance by the phage F-116 from a nosocomial strain of Pseudomonas aeruginosa isolated in Slovakia
Acta Virol.
1994 Oct.
Abstract
Generalized transducting Pseudomonas aeruginosa phage F-116 was propagated in an Imipenem (IMI)-resistant clinical isolate of P. aeruginosa No. 191 and the phage was then used to transduce the IMI-resistance to a susceptible auxotrophic mutant strain of the same species. Transduction seems to be a suitable method for study of resistance determinant(s) and mechanism of resistance in this important species. It was found that the IMI-resistance of the clinical strain No. 191 is caused by production of a betalactamase specifically hydrolyzing this antibiotic.
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