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. 1994 Nov;281(4):415-32.
doi: 10.1016/s0934-8840(11)80328-2.

Characterization of the specific antigenicity of representatives of M. senegalense and related bacteria

G S Besra  1 , S S Gurcha, K H Khoo, H R Morris, A Dell, M E Hamid, D E Minnikin, M Goodfellow, P J Brennan
Affiliations

Characterization of the specific antigenicity of representatives of M. senegalense and related bacteria

G S Besra et al. Zentralbl Bakteriol. 1994 Nov.

Abstract

Representative strains of M. senegalense and an unusual strain, labelled M. farcinogenes (M280) were examined by thin-layer chromatography for the presence of characteristic surface glycolipids. In the case of M. farcinogenes M280 and M. senegalense M264, the glycolipids were of the alkali-labile acyltrehalose lipooligosaccharide (LOS) class of antigens, whereas M. senegalense M263 was found to contain the alkali-stable glycopeptidolipids (GPL). Through a combination of 1H-NMR, methylation analysis, FAB/MS, and other analytical techniques, the structures of these glycolipids were deduced. The LOS glycolipids were found to be similar in structure to the characteristic glucosyltrehalose-based glycolipids isolated previously from clinical isolates of M. fortuitum, but distinct from the diacyltrehaloses characteristic of the type strain of M fortuitum. The glycopeptidolipids from M. senegalense M263 were closely similar to those characterized previously from M.

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