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. 1995 Feb;18(2):193-9.
doi: 10.2337/diacare.18.2.193.

Insulin sensitivity and Lp(a) concentrations in normoglycemic men

S M Haffner  1 , P Karhapaa, D L Rainwater, L Mykkanen, G Aldrete Jr, M Laakso
Affiliations

Insulin sensitivity and Lp(a) concentrations in normoglycemic men

S M Haffner et al. Diabetes Care. 1995 Feb.

Abstract

Objective: Increased lipoprotein(a) [Lp(a)] concentrations have been recognized as a risk factor for coronary heart disease. Little data exists on the relationship of Lp(a) concentrations to insulin resistance.

Research design and methods: We examined insulin resistance (as determined by the euglycemic clamp) together with indirect calorimetry in relation to Lp(a) concentrations, apolipoprotein(a) [apo(a)] molecular weight, and apo(a) phenotype in 87 normoglycemic men.

Results: Lp(a) concentrations were significantly related to total (r = 0.225) and nonoxidative (r = 0.256) whole-body glucose disposal. These results suggest a positive but weak association between insulin sensitivity (restricted to the nonoxidative whole-body glucose disposal) and Lp(a) concentrations. However, after adjustment for apo(a) molecular weight [which accounts for some of the genetic influences on Lp(a) levels], total and nonoxidative body glucose disposal were not significantly related to Lp(a) concentrations.

Conclusions: Normoglycemic insulin-resistant subjects do not have elevated Lp(a) concentrations.

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