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Comparative Study
. 1995 Feb;18(2):241-4.
doi: 10.2337/diacare.18.2.241.

Prospective study of lipoprotein(a) as a risk factor for atherosclerotic cardiovascular disease in patients with diabetes

T Hiraga  1 , T Kobayashi, M Okubo, K Nakanishi, T Sugimoto, Y Ohashi, T Murase
Affiliations
Comparative Study

Prospective study of lipoprotein(a) as a risk factor for atherosclerotic cardiovascular disease in patients with diabetes

T Hiraga et al. Diabetes Care. 1995 Feb.

Abstract

Objective: To assess whether lipoprotein(a) [Lp(a)] is a risk factor for atherosclerotic cardiovascular disease in diabetes.

Research design and methods: We studied 221 patients with non-insulin-dependent diabetes mellitus (NIDDM) without diabetic complications who were followed for 2.2-3.1 years. Their serum Lp(a) levels were semiquantified by a rapid electrophoretic method that accurately discriminates high from low serum Lp(a) at the 20 mg/dl level.

Results: Seven of 105 diabetic patients with a high serum Lp(a) experienced a clinical event related to atherosclerotic cardiovascular disease. This incidence was significantly higher than that of the 110 diabetic patients with a low serum Lp(a). The logistic regression analysis revealed that Lp(a) was an independent risk factor for the event.

Conclusions: Lp(a) is a significant risk factor for atherosclerotic cardiovascular disease in NIDDM.

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