[Diabetes mellitus and control of protein biosynthesis in rat liver (author's transl)]

Abstract

Protein synthesis of liver risobosmes is markedly reduced in diabetes mellitus. This finding is well correlated with the protein catabolic state of insulin deficiency in general and with the reduction of protein synthesis by muscle ribosomes in particular. However, with regard to the mechanism of the amino acid incorporation by muscle ribosomes there is indication for an additional participation of transcription in the diabetes-induced reduction of protein synthesis by liver ribosomes. There is support for the hypothesis of an additional effect of diabetes on ribosomal wash proteins and on synthesis of ribosomal ribonucleic acids with consecutive reduction of conformation of ribosomal subunits or binding of ribosomal subunits to template RNA respectively.