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. 1978 Apr 14;218(1):35-42.
doi: 10.1007/BF00314716.

Myoclonic attacks induced by L-dopa and bromocryptin in Parkinson patients: a sleep EEG study

J Vardi, H Glaubman, J M Rabey, M Streifler

Myoclonic attacks induced by L-dopa and bromocryptin in Parkinson patients: a sleep EEG study

J Vardi et al. J Neurol. .

Abstract

Six patients with Parkinson's disease developed nocturnal myoclonic attacks after prolongued treatment with L-Dopa which were electroencephalographically recorded. These symptoms persisted after treatment with 2 bromo-alpha-ergocryptin (Bromocryptin), a dopamine receptor agonist, which was substituted for L-Dopa. Bromocryptin is known to have no pre- or postsynaptic effect on serotonin metabolism. It is proposed that these myoclonic phenomena are the expression of the hypersensitivity of denervated catecholamine receptors in the brainstem to the stimulation of L-Dopa and Bromocryptin. This thesis differs with previous suggestions that serotonin plays a major role in the genesis of myoclonic seizures in Parkinsonian patients treated with L-Dopa.

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References

    1. Neurology. 1976 May;26(5):405-9 - PubMed
    1. Nature. 1970 Dec 5;228(5275):999-1001 - PubMed
    1. Psychiatry Clin Neurosci. 2001 Jun;55(3):305-10 - PubMed
    1. Electroencephalogr Clin Neurophysiol. 1971 Sep;31(3):269-73 - PubMed
    1. Klin Wochenschr. 1961 Oct 15;39:1056-9 - PubMed