Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Mar 25;23(6):962-6.
doi: 10.1093/nar/23.6.962.

Late induction of human DNA ligase I after UV-C irradiation

A Montecucco  1 , E Savini, G Biamonti, M Stefanini, F Focher, G Ciarrocchi
Affiliations

Late induction of human DNA ligase I after UV-C irradiation

A Montecucco et al. Nucleic Acids Res. .

Abstract

We have studied the regulation of DNA ligase I gene expression in UV-C irradiated human primary fibroblasts. An increase of approximately 6-fold both in DNA ligase I messenger and activity levels was observed 24 h after UV treatment, when nucleotide excision repair (NER) is no longer operating. DNA ligase I induction is serum-independent and is controlled mainly by the steady-state level of its mRNA. The activation is a function of the UV dose and occurs at lower doses in cells showing UV hypersensitivity. No increase in replicative DNA polymerase alpha activity was found, indicating that UV induction of DNA ligase I occurs through a pathway that differs from the one causing activation of the replication machinery. These data suggest that DNA ligase I induction could be linked to the repair of DNA damage not removed by NER.

PubMed Disclaimer

References

    1. Nucleic Acids Res. 1992 Dec 11;20(23):6209-14 - PubMed
    1. Curr Genet. 1986;11(2):107-12 - PubMed
    1. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7491-5 - PubMed
    1. Gene. 1994 Jul 8;144(2):253-7 - PubMed
    1. Cell. 1992 May 1;69(3):495-503 - PubMed

Publication types