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Comparative Study
. 1995 Apr 26;209(3):1039-45.
doi: 10.1006/bbrc.1995.1602.

Annexin VI is secreted in human bile

B Thorin  1 , G Gache, T Dubois, R Grataroli, N Domingo, F Russo-Marie, H Lafont
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Comparative Study

Annexin VI is secreted in human bile

B Thorin et al. Biochem Biophys Res Commun. .

Abstract

A calcium-binding protein of 68 kDa was isolated from human bile that precipitates upon addition of 5 mM CaCl2. This protein was recognized by an immunoaffinity purified anti-annexin VI antibody and it had a similar aminoacid composition as annexin VI. Phospholipase A2 activity was inhibited in vitro in a dose-dependent manner as reported for annexin VI. It is the first time that an annexin secretion is demonstrated in bile.

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