Melanoma cytoplasmic humoral antibody test. A diagnostic adjunct

Abstract

Detecting a high titre of antibody directed against the cytoplasm of malignant melanoma cells can help: To diagnose pigmented skin lesions with awkward histopathological signs. The test is positive in about half of the early primary malignant melanomas and in all actively regressing halo naevi. It is negative in benign juvenile melanoma. To prognosticate and provide a continuing assessment of the course of the disease in patients with known malignant melanoma. The test becomes negative when malignant melanoma metastasizes. To alert patients in danger, such as those who have extensive pigmented naevi or have a family history of malignant melanoma, of the supervention of the disease.