The kinetics of beta-granule formation: a morphometric study
- PMID: 773726
- DOI: 10.1007/BF00428974
The kinetics of beta-granule formation: a morphometric study
Abstract
The rate of formation of beta-granules in mouse islet cells has been studied by morphometry using experimental conditions in which insulin secretion is known to be blocked. The number of beta-granules in a cell is increased by 120%, 45 minutes after a continued glucose stimulus of 16.7 mM. The implications of the results are discussed with respect to the construction of kinetic models for the secretion of insulin by exocytosis.
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