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. 1976 May;12(2):111-4.
doi: 10.1007/BF00428974.

The kinetics of beta-granule formation: a morphometric study

P M Dean

The kinetics of beta-granule formation: a morphometric study

P M Dean. Diabetologia. 1976 May.

Abstract

The rate of formation of beta-granules in mouse islet cells has been studied by morphometry using experimental conditions in which insulin secretion is known to be blocked. The number of beta-granules in a cell is increased by 120%, 45 minutes after a continued glucose stimulus of 16.7 mM. The implications of the results are discussed with respect to the construction of kinetic models for the secretion of insulin by exocytosis.

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