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. 1976 May;12(2):167-70.
doi: 10.1007/BF00428984.

Polyploidy in the pancreas of the normal and diabetic mutant mouse

M G Ehrie, F J Swartz

Polyploidy in the pancreas of the normal and diabetic mutant mouse

M G Ehrie et al. Diabetologia. 1976 May.

Abstract

The DNA content of endocrine and exocrine pancreatic nuclei of normal C57BL/KsJ and diabetic mutant C57BL/Ks-db/db mice was measured by Feulgen microdensitometry. The exocrine and endocrine pancreatic nuclei of the 4-week-old normal, 12-week-old normal, and 4-week-old (prehyperglycaemic) diabetic mutant mice contained diploid and tetraploid cells, while the 12-week-old (established hyperglycaemic) mutant contained diploid, tetraploid, and octaploid nuclei. The polyploidy in the endocrine pancreas of all these mice was confined to the B-cells, while the A-cells were always diploid.

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References

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