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. 1995 May;35(5):389-91.
doi: 10.1046/j.1537-2995.1995.35595259148.x.

Albumin batches and B19 parvovirus DNA

J J Lefrère  1 , M Mariotti, I De la Croix, J Lerable, M Thauvin, T Burnouf, G Folléa
Affiliations

Albumin batches and B19 parvovirus DNA

J J Lefrère et al. Transfusion. 1995 May.

Abstract

Background: B19 parvovirus (B19) may be transmitted iatrogenically by blood, and its prevalence in blood donations is estimated at 1 in 3,300 to 1 in 50,000. As a large number of blood donations make up the plasma pools used to produce plasma derivatives, even a virus as rare as B19 in a population of blood donors may result in the frequent contamination of plasma batches. The percentage of albumin batches containing B19 DNA has never been determined.

Study design and methods: The presence of B19 DNA was investigated by a polymerase chain reaction assay (with a primer pair in the VP1 region) in a total of 12 and 17 batches of 4- and 20-percent albumin, respectively, from two different manufacturers.

Results: No B19 DNA was detected in the batches tested.

Conclusion: The current fractionation process used to obtain these albumin preparations is seen to allow the efficient degradation and/or elimination of B19.

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