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Comparative Study
. 1995 May 5;210(1):205-10.
doi: 10.1006/bbrc.1995.1647.

A three dimensional model for the interaction of MSH with the melanocortin-1 receptor

P Prusis  1 , P A Frändberg, R Muceniece, I Kalvinsh, J E Wikberg
Affiliations
Comparative Study

A three dimensional model for the interaction of MSH with the melanocortin-1 receptor

P Prusis et al. Biochem Biophys Res Commun. .

Abstract

A model for the interaction of the melanocortin-1 (MC1) receptor with MSH peptide has been constructed. The model was built by homology modelling using bacteriorhodopsin as template. A cyclic analogue of MSH could be docked into a binding pocket located between transmembrane (TM) domains 2, 3 and 6 of the receptor. The most significant receptor to ligand interactions occur between D117 in TM3 of receptor with histidine in cyclic MSH-peptide, H260 in TM6 with glutamic in peptide and D121 in TM3 with arginine in peptide. The model finds support from earlier mutagenesis data.

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