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. 1994 Jul;81(7):587-92.

[Study of mdm2 gene amplification in primary breast tumors]

[Article in French]
X Fontana  1 , P Ferrari, M Abbes, J Monticelli, M Namer, F Bussière
Affiliations
  • PMID: 7742600

[Study of mdm2 gene amplification in primary breast tumors]

[Article in French]
X Fontana et al. Bull Cancer. 1994 Jul.

Abstract

mdm2 (mouse double minute) protein seems lead to p53 inactivation and therefore might potentially play a role in carcinogenesis. We have studied mdm2 gene amplification from 239 primary breast cancer tissues. mdm2 gene was amplified in 10% of cases (25/239). mdm2 amplification was associated with c-erbB2 amplification (P < 10(-3)). No other correlation was found. However there was inverse correlation between c-erbB2 gene amplification and hormonal receptors (P < 10(-4)), only from patients without mdm2 gene amplification.

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