[Efficacy of the combination of mitomycin, ifosfamide and cisplatin with irradiation for the treatment of cerebral metastasis in non small cell lung carcinoma]

Abstract

We initiated prospective study testing efficacy of multidrug chemotherapy (cisplatin, ifosfamide, mitomycin) with irradiation in brain metastases of non small cell lung cancer at first diagnosis. Among 22 patients we obtained ten objective local responses (45%). Median survival was 7 months. Toxicity was mild (> 2 - OMS): hematologic = five patients; gastrointestinal = one patient. Among 11 patients who received chemotherapy before radiotherapy we had seven objective responses (patients evaluated after three courses of chemotherapy and before radiotherapy). This result indicates the interest of this protocol of chemotherapy in brain metastases. The association of this protocol of chemotherapy and radiotherapy appears effective, well tolerated and few toxic.