Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 May 1;14(9):1932-41.
doi: 10.1002/j.1460-2075.1995.tb07185.x.

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice

I Screpanti  1 , L Romani, P Musiani, A Modesti, E Fattori, D Lazzaro, C Sellitto, S Scarpa, D Bellavia, G Lattanzio, et al.
Affiliations

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice

I Screpanti et al. EMBO J. .

Erratum in

  • EMBO J 1995 Jul 17;14(14):3596

Abstract

C/EBP beta is considered a key element of interleukin-6 (IL-6) signalling as well as an important transcriptional regulator of the IL-6 gene itself. We describe here how mice lacking C/EBP beta develop a pathology similar to mice overexpressing IL-6 and nearly identical to multicentric Castleman's disease in human patients, with marked splenomegaly, peripheral lymphadenopathy and enhanced haemopoiesis. Humoral, innate and cellular immunity are also profoundly distorted, as shown by the defective activation of splenic macrophages, the strong impairement of IL-12 production, the increased susceptibility to Candida albicans infection and the altered T-helper function. Our data show that C/EBP beta is crucial for the correct functional regulation and homeostatic control of haemopoietic and lymphoid compartments.

PubMed Disclaimer

References

    1. J Clin Oncol. 1985 Sep;3(9):1202-16 - PubMed
    1. Eur J Immunol. 1993 May;23(5):1034-8 - PubMed
    1. Nature. 1986 Oct 2-8;323(6087):445-8 - PubMed
    1. Cell. 1986 Dec 5;47(5):767-76 - PubMed
    1. Cell. 1987 Nov 6;51(3):503-12 - PubMed

Publication types

MeSH terms

LinkOut - more resources